Wegovy vs Mounjaro: Which Is Right for You?
A detailed side-by-side comparison of Wegovy and Mounjaro, including cost, side effects, dosing, and provider availability.
At a Glance
Wegovy
FDA ApprovedMounjaro
FDA ApprovedDetailed Comparison
| Feature | Wegovy | Mounjaro |
|---|---|---|
| Active Ingredient | semaglutide | tirzepatide |
| Manufacturer | Novo Nordisk | Eli Lilly |
| FDA Approved | Yes | Yes |
| FDA Indication | Chronic weight management | Type 2 Diabetes (off-label for weight loss) |
| Dosing Schedule | Once weekly | Once weekly |
| Administration | Subcutaneous injection (pen) | Subcutaneous injection (pen) |
| Starting Price (lowest provider) | N/A | N/A |
| Provider Count | 19 | 15 |
| Insurance Coverage | 12 providers | 10 providers |
| Weight Loss Data | The STEP 1 trial showed patients on Wegovy lost an average of 14.9% of body weight (about 33 lbs) over 68 weeks. In the STEP 3 trial, which combined W... | In the SURMOUNT-1 trial, patients on the highest dose of tirzepatide (15mg) lost an average of 22.5% of body weight over 72 weeks - the highest weight... |
How They Compare
Wegovy and Mounjaro represent two distinct approaches to GLP-1 based weight management. Wegovy contains semaglutide, a GLP-1 receptor agonist, while Mounjaro contains tirzepatide, a dual GIP/GLP-1 receptor agonist. The dual mechanism of tirzepatide targets two incretin pathways simultaneously, which clinical trials suggest may produce greater average weight loss. However, both medications have proven effective, and the best choice depends on individual factors including insurance coverage, side effect tolerance, and provider availability.
Side Effects Comparison
Wegovy
Common
- Nausea (44% of patients, usually temporary)
- Diarrhea (30%)
- Vomiting (24%)
- Constipation (24%)
- Abdominal pain
- Headache
- Fatigue
Serious (Rare)
- Pancreatitis
- Gallbladder problems
- Kidney injury
- Suicidal thoughts (rare, under investigation)
- Thyroid C-cell tumors (boxed warning, animal studies)
- Hypoglycemia when combined with insulin
Mounjaro
Common
- Nausea (most common during dose escalation)
- Diarrhea
- Decreased appetite
- Vomiting
- Constipation
- Indigestion
- Abdominal pain
Serious (Rare)
- Pancreatitis
- Gallbladder problems
- Hypoglycemia (especially with insulin)
- Kidney problems
- Allergic reactions
- Thyroid C-cell tumors (boxed warning, animal studies)
Dosing Schedule Comparison
Wegovy
Subcutaneous injection (pen) - Once weekly
Mounjaro
Subcutaneous injection (pen) - Once weekly
Frequently Asked Questions
What is the difference between Wegovy and Mounjaro?
Wegovy (Semaglutide) is made by Novo Nordisk and is FDA-approved. Mounjaro (Tirzepatide) is made by Eli Lilly and is FDA-approved. Wegovy uses semaglutide (a GLP-1 agonist) while Mounjaro uses tirzepatide (a dual GIP/GLP-1 agonist), which may produce different weight loss results.
Which is more affordable, Wegovy or Mounjaro?
Based on available providers, Wegovy starts at $0/month while Mounjaro starts at $0/month. Both have similar starting prices. Actual costs depend on your provider, insurance coverage, and dose level.
Which is more effective for weight loss, Wegovy or Mounjaro?
Both medications have shown significant weight loss results. Clinical trials suggest tirzepatide (dual GIP/GLP-1 agonist) may produce slightly greater average weight loss than semaglutide (GLP-1 agonist alone), though individual results vary significantly. Your healthcare provider can help determine which is best for your specific situation.
Can I switch from Wegovy to Mounjaro?
Switching between GLP-1 medications is possible but should always be done under medical supervision. Your provider will determine the appropriate starting dose for the new medication and may adjust the transition schedule based on your current dose and response. Since these medications use different active ingredients, your provider may need to restart the dose escalation process.
Related Comparisons
Medical Disclaimer: This comparison is for educational purposes only and should not replace professional medical advice. Individual results vary. Always consult your healthcare provider before starting or changing any medication.